Chinese scientists have uncovered a hidden metabolic interaction between breast cancer cells and immune cells that promotes tumor growth and resistance to immunotherapy. The study, published in Cancer Cell on April 3, was led by Professor Hu Hai and collaborators from several Chinese institutions.
Researchers found that breast cancer cells produce large amounts of the amino acid arginine, which they use to reprogram nearby immune cells called tumor-associated macrophages (TAMs). These TAMs, in turn, suppress the immune system’s CD8+ T cells, which are key to fighting cancer. The TAMs convert arginine into polyamines, altering their genetic programming to support tumor growth and immune evasion.
By disrupting arginine metabolism, the researchers were able to restore immune function and slow tumor growth in preclinical models. They propose combining arginine- or polyamine-targeting therapies with immunotherapy to overcome resistance and improve treatment outcomes.
Although focused on breast cancer, the findings may apply to other cancers, offering a promising new path for precision cancer treatment.
Source – CGTN
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